New research indicates that individuals who come off popular weight-loss injections like semaglutide or tirzepatide tend to recover reduced body mass much more quickly than those who stop traditional diet and exercise regimens.
Research printed in a prominent medical journal points out that while obese people can lose about a fifth of their body weight while on the medication, the weight returns at an estimated rate of nearly a kilo each month after stopping.
"Individuals buying such medications must be aware of the potential of quick weight regain when the medication is stopped," cautioned lead investigator Dr. Susan Jebb.
Such speed of recovery means a reversion to original weight within about 18 months.
Analyzing Approaches
The research, which examined dozens of studies involving over 9,000 of participants, contrasted the effects of these new drugs with older methods.
Researchers emphasize that people who lose weight through diet and exercise typically have a less rapid weight regain—perhaps 100 grams monthly—post-intervention.
Explaining the Rapid Regain
Doctors believe the mechanism of the drugs accounts for the amplified rebound.
GLP-1 drugs imitate a natural hormone called glucagon-like peptide-1, which helps regulate feelings of fullness.
"Long-term administration of the hormone concentrations far above than normal could lead to the system to generate a reduced amount of its own natural GLP-1, and may also reduce responsiveness to its effects," explained Dr. Adam Collins, a nutrition expert.
"Stopping of this GLP-1 'fix' results in hunger is no longer kept in check, making excessive eating a significant risk."
A Chronic Issue?
Health authorities advise the jabs for individuals with obesity-related health risks, alongside prescribed lifestyle changes.
Many experts argue that, considering the significant potential of weight regain, the therapy might need to be long-term.
This opinion is echoed by pharmaceutical companies, who say that the results "emphasize the chronic character of excess weight," akin to managing conditions like high blood pressure.
Patient Testimonies
Individuals who have come off the jabs report a powerful return of appetite.
"It was like something flipping and you become starving," recalled an individual.
This challenge is worsened if individuals have not developed lasting dietary or behavioural modifications during treatment.
Significant Use
Figures show that millions of adults in the UK have tried these injections in the last 12 months, with desire continuing to grow.
- Use is more common among women than men.
- The middle-aged demographic shows the greatest level of interest.
- A large proportion access the medications through private prescriptions rather than public health services.
Ultimately, clinicians stress that while the jabs are potent agents for weight loss, they are not a magic solution and lasting health benefits relies on combined lifestyle management.
